Product Details
Catalog Number: RA25029
Applications: WB
Type: Rabbit IgG
Immunogen: Peptide corresponding to residues surrounding Thr668 of human APP695
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 322
UniProt: O00213
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$295.00Add to Cart

Amyloid precursor protein (APP) plays a central role in the pathogenesis of Alzheimer's disease (AD). FE65 is a signaling adaptor of APP protein. The FE65/APP complex was shown to translocate into the cell nucleus and regulate gene expression. Genetic studies in mice validated FE65-APP interaction and molecular studies provided evidence on the role of the complex in abnormal signaling detected in brains of Alzheimer Disease patients.

Images

Western blot analysis using FE65 and HEK 293 cell lysates.

Western blot analysis using FE65 and HEK 293 cell lysates.