Product Details
Catalog Number: RA25065
Applications: WB
Type: Mouse IgG
Immunogen: SDS denatured, recombinant bovine aromatic DOPA decarboxylase (DDC) expressed in E. coli and purified from inclusion bodies.
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Protein G Purified
Format B: liquid
Species Reactivity: Rat
Entrez: 1644
UniProt: P20711
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$325.00Add to Cart

Dopa decarboxylase (DDC), also known as AADC, is a homodimeric vitamin B6-dependent enzyme that catalyzes the decarboxylation of hydroxylated aromatic amino acids.  DDC is expressed in the adrenal medulla and catecholaminergic neurons. It catalyzes the final step in the synthesis of the neurotransmitters dopamine and serotonin. Defects in DDC are associated with the development of schizophrenia, Parkinson's disease, and hypertension. Human DDC shares 89% aa sequence identity with mouse and rat DDC.

Images

Western blot of rat adrenal medulla. As shown in the autoradiograph, the antibody is specific for the ~55k DDC protein.

Western blot of rat adrenal medulla. As shown in the autoradiograph, the antibody is specific for the ~55k DDC protein.