Product Details
Catalog Number: RA25087
Applications: ICC, IP, IF
Type: Rabbit IgG
Immunogen: Synthetic peptide (Human) - which represents a portion of human Mammalian Target of Rapamycin encoded in part by exons 5 and 6.
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Rat
Entrez: 2475
UniProt: P42345
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$425.00Add to Cart

Mammalian target of rapamycin (mTOR) regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, and transcription. It is is activated in response to nutrients, growth factors and cellular energy.

Dysregulated mTOR signaling has been implicated in major diseases These include: cancer, metabolic disorders, neurological diseases, and inflammation. For example, findings demonstrate mTOR signaling hyperactivity in Alzheimer's Disease (AD) brains.

Images

mTOR (red) staining of L6 myotubes. Nuclei are stained with nuclear antigen antibody (green).

mTOR (red) staining of L6 myotubes. Nuclei are stained with nuclear antigen antibody (green).

mTOR protein kinase assay: mTOR (dilution -1:1000) immunoprecipitates were incubated at 30°C with recombinant 4E-BP1 and 32P-gATP. Autoradiograph shows 32P incorporated into 4E-BP1.

mTOR protein kinase assay: mTOR (dilution -1:1000) immunoprecipitates were incubated at 30°C with recombinant 4E-BP1 and 32P-gATP. Autoradiograph shows 32P incorporated into 4E-BP1.