Product Details
Catalog Number: RA25095
Applications: ICC, WB, IP, IF
Type: Rabbit IgG
Immunogen: A synthetic peptide made to an N-terminal portion of the human JARID2 or jumonji protein sequence (between residues 1-100).
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse
Entrez: 3720
UniProt: Q92833
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$379.00Add to Cart

JARID2 or the Jumonji protein is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators. It is essential for embryogenesis, including neural tube formation. It plays a key role in differentiation of embryonic stem cells and normal development. Defects in JARID2, characterized by PRC1 and PRC2 mutants, show a severely compromised capacity for successful differentiation towards neural or mesodermal fates.

JARID2 is an excellent marker for studying differentiation patterns in induced pluripotent stem cells (iPSCs) and embyonic stem cells (eSCs).

Images

JARID2 staining of HeLa cells using a DyLight 488 conjugated secondary antibody.

JARID2 staining of HeLa cells using a DyLight 488 conjugated secondary antibody.

Western blot detection of JARID2 protein in E16 mouse brain lysates.

Western blot detection of JARID2 protein in E16 mouse brain lysates.