Human vimentin is a 53,521 dalton protein (466 amino acids) expressed in many cell types of mesodermal origin, and is one of the intermediate filament types that form the cytoskeleton. In the embryonic nervous system, however, vimentin is expressed by migrating neural crest cells forming the PNS, and by neural stem cells of the CNS. In some forms of glioblastoma, vimentin is re-expressed by the tumor cells and serves as a general indicator of their undifferentiated state.
Immunohistochemical staining for Vimentin is also characteristic of sarcomas (of neural, muscle and fibroblast origin) compared to carcinomas which are generally negative. Melanomas, lymphomas and vascular tumors may all stain for Vimentin. Vimentin antibodies are thus of value in the differential diagnosis of undifferentiated neoplasms and malignant tumors.
- Product Reviews
- Related Products
Name Catalog # GFAP CH22102 Vimentin CH23010 GFAP CH23011 Coronin 1a/p57 CH23017 CD11b (OX-42) CH23021 GDNF Receptor Alpha 1 GT15004 GDNF Receptor Alpha 1 Biotinylated GT15004B GDNF Receptor Alpha 2 GT15005 GDNF Receptor Alpha 2 Biotinylated GT15005B GDNF GT15007 GDNF Biotinylated GT15007B GDNF Receptor Alpha 4 GT15083 SOX2 GT15098 GDNF Receptor Alpha 1 GT15108 GDNF Receptor Alpha 3 GT15123 TROY/TNFRSF19 GT15223 TROY/TNFRSF19, Biotinylated GT15332B SOX2 MO15040 GFAP MO15052 GDNF Receptor Alpha 1 MO15093 GAP43 MO22118 Galectin-3 (LGAS3) MO22119 Aldolase C MO22135 GFAP MO22136 ALDH1L1 MO22143 Aldehyde Dehydrogenase H1L1 (ALDH1L1) MO22155 Aldolase C MO22156 Aldolase C (C-terminus Specific) MO22157 ATPase Na+/K+ transporting alpha 1 MO25023 GFAP MO45001 PTEN-induced kinase/PINK1 RA19013 Survivin RA19022 GFAP RA22101 Coronin 1a/p57 RA22108 GAP43 RA22115 ALDH1L1 RA22119 xCT RA25026 GAP43 RA25086 GDNF Receptor Alpha 3 RA30017