Product Details
Catalog Number: CH23008
Applications: ICC, WB, IHC
Type: Chicken IgY
Dilutions: ICC 1:50-1:100; IHC 1:50-1:100; WB 1:50-1:100
Immunogen: Peptide common to mouse mouse (P60202) and human (NP_000524) PLP
Storage: Store at 4°C in the dark
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$99.00Add to Cart

Human PLP (also known as lipophilin) is a 29,946 dalton protein (277 amino acids) found in myelin of the CNS and PNS. Expressed by oligodendrocytes and Schwann cells, PLP stabilizes myelin by preventing lipid bilayer fusion, and aids in its compaction. Different mutations of the human PLP gene product result in two neurological disorders -- Pelizaeus-Merzbacher disease and Spastic Paraplegia type 2. 

Images

In this tissue section through an e13 mouse brain, PLP (green staining) can be seen in immature oligodendrocytes of white matter tracts. DAPI (blue staining) allows visualization of nuclei.

In this tissue section through an e13 mouse brain, PLP (green staining) can be seen in immature oligodendrocytes of white matter tracts. DAPI (blue staining) allows visualization of nuclei.