Product Details
Catalog Number: CH23015
Applications: IHC
Type: Chicken IgY
Immunogen: Purified neurofilament protein (200 kDa) isolated from bovine brains
Storage: Store at 2° - 8° C
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse
Downloads: Datasheet (pdf)
Product Sizes
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200 ul$285.00Add to Cart

Neurofilaments can be defined as the intermediate or 10nm filaments found in specifically in neuronal cells. In the electron microscope neurofilaments appears as 10nm diameter fibres of indeterminate length which generally have fine wispy protrusions from their sides. They are found particularly abundantly in axons of large projection neurons. Antibodies to the various neurofilament subunits are very useful cell type markers since the proteins are among the most abundant of the nervous system, are expressed only in neurons, and are biochemically very stable.

Some studies have shown that levels of neurofilament heavy and neurofilament light are elevated in patients with Alzheimer's disease, frontotemporal lobe dementia, and vascular dementia.  

Images
NF-H-positive cultured neuron (green) from a neonatal mouse brain. Protocol on datasheet

NF-H-positive cultured neuron (green) from a neonatal mouse brain. Protocol on datasheet

NF-H-positive cultured neuron (green) from a neonatal mouse brain. Protocol on datasheet

NF-H-positive cultured neuron (green) from a neonatal mouse brain. Protocol on datasheet