Product Details
Catalog Number: CH23019
Applications: IHC
Type: Chicken IgY
Immunogen: Recombinant mouse PAP protein was expressed using a baculoviral-delivery system.
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Mouse, Rat
Downloads: Datasheet (pdf)
Product Sizes
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200 ul$295.00Add to Cart

Mouse PAP is a 43,698 dalton protein (381 amino acids; NCBI accession numberAAF23171) associated with prostatic cancer cells, as well as primary afferent sensory neurons involved in the pain pathway. This protein is an enzyme that dephosphorylates adenosine monophosphate (AMP) in the dorsal horn gray matter of the spinal cord, generating free adenosine. Injections of PAP into the dorsal horn of experimental mice has been shown to decrease pain perception by acting in an antinociceptive, antihyperalgesic, and antiallodynic fashion.

This makes PAP is an excellent marker for studying the neurotransmission of nociceptive and neuropathic pain.

Images

Tissue sections through a 10%-formalin fixed adult mouse. Sections were examined for PAP positive dorsal root ganglion sensory neurons. Secondary antibodies (fluorescein-labeled goat anti-chicken IgY, Neuromics Cat. #CH23101) were used at a concentration of 1:500.

Tissue sections through a 10%-formalin fixed adult mouse. Sections were examined for PAP positive dorsal root ganglion sensory neurons. Secondary antibodies (fluorescein-labeled goat anti-chicken IgY, Neuromics Cat. #CH23101) were used at a concentration of 1:500.