Product Details
Catalog Number: MO18002
Applications: WB, IHC, IP, IF
Type: Mouse IgG
Immunogen: Native bovine tau and the epitope maps to the carboxy-terminus of the protein.
Format A: Protein G Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$332.00Add to Cart

Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5. Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer's disease. Furthermore, inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies.

IHC Image:  Tau staining of paraffin-embedded Alzheimer's brain.

WB Image: Western blot analysis of extracts from mouse and rat brain.

Images