Product Details
Catalog Number: MO20011
Applications: IHC
Type: Mouse IgM
Immunogen: Prokaryotic recombinant protein corresponding to the external domain of the human transforming growth factor beta receptor type 1 molecule.
Format A: Supernatant
Format B: liquid
Species Reactivity: Human
Downloads: SDS (pdf)
Downloads: Datasheet (pdf)
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Transforming growth factor beta (TGFB) inhibits cell proliferation and stimulates cell differentiation. This is achieved through a receptor complex of types I and II TGFB receptors. The type II receptor is a transmembrane serine/threonine kinase which is able to bind TGFB and transactivate the type I receptor. TGFB receptors are found in all myometrial tissues and, in the kidney, they are found exclusively in renal tubular cells. In normal gastric mucosa, type I and II receptors are demonstrated in fundic glands, but not on surface mucous cells and in normal small bowel and colon, TGFB receptors are expressed in the epithelial cells of the upper crypts.

Image: TGF Beta R (Type1) staining of paraffin embedded Human colon, ulcerative colitis. Note membrane staining of a proportion of epithelial cells and lymphocytes.

TGF-βR1: Customer Publications