Transforming growth factor beta (TGFB) inhibits cell proliferation and stimulates cell differentiation. This is achieved through a receptor complex of types I and II TGFB receptors. The type II receptor is a transmembrane serine/threonine kinase which is able to bind TGFB and transactivate the type I receptor. TGFB receptors are found in all myometrial tissues and, in the kidney, they are found exclusively in renal tubular cells. In normal gastric mucosa, type I and II receptors are demonstrated in fundic glands, but not on surface mucous cells and in normal small bowel and colon, TGFB receptors are expressed in the epithelial cells of the upper crypts.
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- Kenichi Harada, Yasunori Sato, Hiroko Ikeda, Kumiko Isse, Satoru Ozaki, Mio Enomae, Kazunori Ohama, Kazuyoshi Katayanagi, Hiroshi Kurumaya, Akira Matsui, Yasuni Nakanuma. (2008). Epithelial-mesenchymal transition induced by biliary innate immunity contributes to the sclerosing cholangiopathy of biliary atresia. The Journal of Pathology, Volume 217 Issue 5, Pages 654 - 664. doi: 10.1002/path.2488
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