Product Details
Catalog Number: MO22128
Applications: WB, IF
Type: Mouse IgG
Immunogen: Whole purified bovine rhodopsin protein.
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat, Bovine, Porcine
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
100 ul$295.00$225.00Add to Cart

Rhodopsin is the protein in the mammalian retina responsible for the light sensitivity of rod cells, which are responsible for vision in low light levels. The rhodopsin protein is a member of the G protein-coupled receptor (GPCR) rhodopsin-like family. It exists with a the ligand bound subsatnce named retinal. Retinal can exist in two isomeric forms, 11-cis and 11-trans retinal. In the dark rhodopsin is associated with 11-cis retinal, but light causea the 11-cis form to flip to the 11-trans form, and this causes an alteration in the structure of the rhodopsin making it catalytically active resulting in a reduced rate of photoreceptor synaptic release. Activity is shut off by phosphorylation under the influence of rhodopsin kinase, the activity of which results in binding of visual arrestin (a.k.a. arrestin-1 and S-antigen), which prevents rhodopsin from interacting with and activating more transducin molecules.

Defects in Rhodopsin are the cause of retinitis pigmentosa type 4. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

Product Reviews
Related Products
NameCatalog #
Frizzled 4/CD344GT15217
Vasopressin V1B ReceptorGT41005
Corticotropin Releasing Hormone Receptor 1GT41006
Vasopressin V1B ReceptorGT41021
APJ (Apelin Receptor)MO15011
Somatostatin Receptor-2-SSTR2MO15109
Rhodopsin (B630)MO22127
Orphanin FQ/NociceptinRA10106
Alpha 2a Adrenergic ReceptorRA14110
Bradykinin Receptor B2RA14137
Alpha 2c Adrenergic ReceptorRA19064
Somatostatin Receptor-1-SSTR1RA25004
Somatostatin Receptor-2-SSTR2RA25005
Frizzled 7RA30031
Frizzled 9RA30032