VR1 Blocking Peptide; specific to GP14100
VR1 (vanilloid receptor 1) is a channel activated by capsaicin, the pungent ingredient in hot peppers. It was isolated from sensory neurons. Sequence analysis suggests that VR1 has six transmembrane domains and intracellular N- and C-termini. It shares structural similarities with the family of putative store-operated calcium channels. VR1 is expressed by nociceptive sensory neurons. It is activated by noxious heat and is thought to function as transducer of noxious thermal stimuli.
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- Abraham B. Beckers, Ellen Wilms, Zlatan Mujagic, Béla Kajtár, Kata Csekő, Zsa Zsa R. M. Weerts, Lisa Vork, Freddy J. Troost, Joanna W. Kruimel, José M. Conchillo, Zsuzsanna Helyes, Ad A. M. Masclee, Daniel Keszthelyi, and Daisy M. A. E. Jonkers. (2021). Age-Related Decrease in Abdominal Pain and Associated Structural- and Functional Mechanisms: An Exploratory Study in Healthy Individuals and Irritable Bowel Syndrome Patients. Frontiers in Pharmacology. doi: 10.3389/fphar.2021.806002
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