Product Details
Catalog Number: RA14135
Applications: IHC
Type: Rabbit IgG
Immunogen: CEKQHELIKLIIQKME-amide
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Whole serum
Format B: liquid
Species Reactivity: Human, Rat
Entrez: 8989
UniProt: O75762
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
100 ul$275.00Add to Cart

Transient receptor potential ion channels (TRPCs) are a superfamily of six transmembrane segment-spanning, gated cation channels. TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction. It is a transformation-associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons. Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage. It is now known that TRPA1 protein is also widely expressed outside of the CNS and is dys-regulated during oncogenic transformation.

Images
TRPA1 staining of rat DRG using FITC-conjugated donkey anti-rabbit  secondary antibodies (green color) and propidium iodide as a counterstain.

TRPA1 staining of rat DRG using FITC-conjugated donkey anti-rabbit secondary antibodies (green color) and propidium iodide as a counterstain.

TRPA1 staining of rat DRG using FITC-conjugated donkey anti-rabbit  secondary antibodies (green color) and propidium iodide as a counterstain.

TRPA1 staining of rat DRG using FITC-conjugated donkey anti-rabbit secondary antibodies (green color) and propidium iodide as a counterstain.

Immunofluorescent staining for (A) TRPA1 in the human normal dental pulp is completely abolished by (B) preadsorption with a control peptide, proving the specificity of the TRPA1 antiserum (×200, scale bars = 50 μm). doi.org/10.1016/j.joen.2012.04.024.

Immunofluorescent staining for (A) TRPA1 in the human normal dental pulp is completely abolished by (B) preadsorption with a control peptide, proving the specificity of the TRPA1 antiserum (×200, scale bars = 50 μm). doi.org/10.1016/j.joen.2012.04.024.