Mutations in the PTEN-induced kinase (PINK1) gene located within the PARK6 locus on chromosome 1p35-p36 have recently been identified in patients with recessive early-onset Parkinson disease. Data suggests that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance.
Image: In active lesions PINK1 immunostaining was intense in reactive astrocytes (arrows). Double labeling of PINK1 (green) with the astrocytic marker GFAP (red) demonstrated PINK1 expression in astrocytes (inset).
Note: Jack Van Horssen et al. ,using this PINK1, showed IHC staining of astrocytes in temporal neocortical tisue harvested from AD and MD patients postmortem (in AD,PINK1 was found to colocalize with classic senile plaques and vascular amyloid depositions). see Free Radical Biology and Medicine. Volume 50, Issue 3, 1 February 2011, Pages 469-476.
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- Micha M.M. Wilhelmus, Susanne M.A. van der Pol, Quentin Jansen, Maarten E. Witte, Paul van der Valk, Annemieke J.M. Rozemuller, Benjamin Drukarch, Helga E. de Vries and Jack Van Horssen. (2011). Association of Parkinson disease-related protein PINK1 with Alzheimer disease and multiple sclerosis brain lesions. Free Radical Biology and Medicine, Volume 50, Issue 3, Pages 469-476. doi: 10.1016/j.freeradbiomed.2010.11.033
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