Product Details
Catalog Number: RA19022
Applications: WB
Type: Rabbit IgG
Dilutions: WB 1:500 - 1:1000
Immunogen: EETAKKVRRAIEQLAAMD (a.a. 125-142) of human Survivin
Storage: Maintain at +2-8 degrees C for 3 months or at -20 degrees C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Downloads: Datasheet (pdf)
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100 ug$225.00Add to Cart

Survivin encodes a structurally unique inhibitor of apoptosis (IAP). Survivin expression is turned off during fetal development and is not found in non-neoplastic adult human tissues. Survivin becomes abundantly re-expressed in transformed cells and in all of the most common cancers of lung, colon, pancreas, breast and prostate in vivo. Survivin appears to be situated at the crossroads of cell death and cell division, governing a checkpoint involved in cytokinesis while also suppressing apoptosis.

Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury. Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein). Survivin might affect regulation of neural cell proliferative responses after brain injury.

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