Product Details
Catalog Number: RA21002
Applications: IHC
Type: Rabbit IgG
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat, Primate
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
50 ug$155.00Add to Cart

Endomorphins are recently discovered endogenous opioid peptides composed of four amino acids: Endomorphin-1 (EM-1) is Tyr-Pro-Trp-Phe-NH2, and  Endomorphin-2 (EM-2) is Tyr-Pro-Phe-Phe-NH2. These peptides have a very high affinity and specificity for mu-opioid receptors as it has been reported in many pharmacological studies. EM-1 is distributed in many brain regions, whereas EM-2 is prevalent in brainstem and spinal cord.  EM-1 and EM-2 exert their antinociceptive activity by interacting with mu-opioid receptors. EM-1 anf EM-2 bind with mu-opioid receptor with high affinity and selectivity in comparison with binding to opioid delta and kappa receptors. EM-1 and EM-2 tetrapeptides activate G-proteins and inhibit adenylyl cyclase activity when bind to mu-opioid receptors.

Image: Endomorphin-1 and 2 staining in rat paraventricular thalamic nucleus.

Note: Our affinity-purified  anti-END-1 antibody  antibody labels neuronal fibers in various brain regions including (but not limited to) thalamic nuclei, periaqueductal gray matter, amygdala, locus coeruleus, nucleus accumbens, parabrachial nucleus, nucleus tractus solitarius and septum. Our affinity-purified anti  labels anti-END-2 antibodiy neuronal processes in spinal cord dorsal horn and trigeminal tract, and label neuronal cell bodies in thalamus. EM-1 and 2 distribution in brain overlaps with mu-opioid receptors.