TREK-1 is a two-pore-domain background potassium channel expressed throughout the central nervous system. It is opened by polyunsaturated fatty acids and lysophospholipids. As well, it is regulated by various neurotransmitters. It has been shown that alterations in the functioning, regulation, or both of the TREK-1 channel may alter mood. TREK-1 is also activated by volatile anesthetics and has been suggested to be an important target in the action of these drugs. Therefore, this particular K+ channel emerges as a potential innovative target for developing new therapeutic agents for anesthesiology and neurology, such as antidepressants.
Image: Detection of TREK 1 in human brain membrane lysate.
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Name Catalog # ATPase Na+/K+ transporting alpha 1 MO25023 KChIP1 K+ channel MO50011 KChIP2b K+ channel MO50012 Kir2.1 K+ channel MO50013 Kir2.2 K+ channel MO50014 Kv1.1 K+ channel MO50015 Kv1.2 K+ channel MO50016 Kv1.3 K+ channel MO50017 Kv1.4 K+ channel MO50018 Kv2.1 K+ channel MO50019 Kv3.1b K+ channel MO50020 Kv4.2 K+ channel MO50021 Kv7.1/KCNQ1 K+ channel MO50022 Kv7.2/KCNQ2 K+ channel MO50023 Kv3.1 K+ channel (pSer503) RA25020