Product Details
Catalog Number: CH23018
Applications: ICC, IHC
Type: Chicken IgY
Immunogen: Chicken synthetic peptide/keyhole limpet hemocyanin (KLH) conjugates corresponding to two regions of the Tau gene product. These peptides corresponded to sequences shared between the mouse (P01637) and human (NP_05819) proteins, and did not contain any of the serine and threonine residues known to undergo phosphorylation.
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Downloads: Datasheet (pdf)
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100 ul$99.00Add to Cart

Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5. Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer's disease. Furthermore, inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies.