Four chromosomal loci (PARK2, PARK6, PARK7, and PARK9) associated with autosomal recessive, early onset parkinsonism are known. Positional cloning within the refined PARK7 critical region recently identified mutations in the DJ-1 gene in PARK7-linked families. Mutations in the PARK7/DJ-1 gene cause autosomal-recessive Parkinson’s disease.
Image: DJ-1 Western Blot of rat primary cortical astrocytes. Red pseudo-coloring shows beta actin around 42kDa and DJ-1 around 24kDa. This blot was also labeled for heme oxygenase 1 which is pseudo-colored green around 27kDa. Courtesy of Amanda Titler, Duquesne University.
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- Guo J, Gao J, Yu X, Luo H, Xiong X, Huang O. (2015). Expression of DJ-1 and mTOR in Eutopic and Ectopic Endometria of Patients with Endometriosis and Adenomyosis. Gynecol Obstet Invest, doi: 10.1159/000365569
- Steven J. Mullett and David A. Hinkle. (2009). DJ-1 knock-down in astrocytes impairs astrocyte-mediated neuroprotection against rotenone. Neurobiology of Disease, Volume 33, Issue 1, Pages 28-36. doi: 10.1016/j.nbd.2008.09.013
- Amanda K. Ashley, William H. Hanneman, Takeshi Katoh, Julie A. Moreno, Ashley Pollack, Ronald B. Tjalkens, and Marie E. Legare. (2009). Analysis of targeted mutation in DJ-1 on cellular function in primary astrocytes. Toxicology Letters, Volume 184, Issue 3, Pages 186-191. doi: 10.1016/j.toxlet.2008.11.008
- Liu, Fang; Nguyen, Jamie L.; Hulleman, John D.; Li, Li; Rochet, Jean-Christophe. (2008). Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease. Journal of Neurochemistry, 105(6):2435-2453. doi: 10.1111/j.1471-4159.2008.05333.x
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