Product Details
Catalog Number: RA25001
Applications: ICC, WB, IHC, IF
Type: Rabbit IgG
Immunogen: Synthetic peptide at the c-terminus of rat NK-1 conjugated to bovine thyroglobulin. Amino Acid Sequence is 393-407=KTMTESSSFYSNMLA
Format A: Whole serum
Format B: liquid
Species Reactivity: Human, Mouse, Rat, Guinea Pig
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$245.00Add to Cart

The tachykinins belong to an evolutionary conserved family of peptide neurotransmitters that share the c-terminal sequence Phe-X-Gly-Leu-Met-NH2 and have an established role in neurotransmission. The mammalian tachykinins include substance P, neurokinin A (NKA) and neurokinin B (NKB) which exert their effects by binding to specific receptors. Tachykinin peptides are important in the mediation of many physiological and pathological processes including inflammation, pain, migraine headache and allergy induced asthma.

Image: NK 1 staining of lamina III neuron in the spinal cord of a rat. IHC Protocol.Customer Testimonial:  Just wanted to let you know that I tried the NK1-r antibody using DAB staining in IHC at 1:5000 dilution on rat spinal cord and it worked very well. Soma Bose, McClintock Lab, Univesity of Kentucky.

Three tachykinin receptor types have been characterized, NK-1, NK-2 and NK-3 which have preferential affinities for SP, NKA and NKB respectively. All three receptors share a high degree of sequence homology, have seven transmembrane spanning domains and similar signal transduction mechanisms (e.g. G-protein coupled activation of phospholipase C).

NK-1: Customer Publications 

Images