The tachykinins belong to an evolutionary conserved family of peptide neurotransmitters that share the c-terminal sequence Phe-X-Gly-Leu-Met-NH2 and have an established role in neurotransmission. The mammalian tachykinins include substance P, neurokinin A (NKA) and neurokinin B (NKB) which exert their effects by binding to specific receptors. Tachykinin peptides are important in the mediation of many physiological and pathological processes including inflammation, pain, migraine headache and allergy induced asthma.
Image: NK 1 staining of lamina III neuron in the spinal cord of a rat. IHC Protocol.Customer Testimonial: Just wanted to let you know that I tried the NK1-r antibody using DAB staining in IHC at 1:5000 dilution on rat spinal cord and it worked very well. Soma Bose, McClintock Lab, Univesity of Kentucky.
Three tachykinin receptor types have been characterized, NK-1, NK-2 and NK-3 which have preferential affinities for SP, NKA and NKB respectively. All three receptors share a high degree of sequence homology, have seven transmembrane spanning domains and similar signal transduction mechanisms (e.g. G-protein coupled activation of phospholipase C).
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Name Catalog # CGRP CH14100 Neurotensin Receptor 1 (NTS1) CH14110 ACE/CD143 FC15000 Neurotensin Receptor 1 (NTS1) GP14020 Substance P GP14103 PGP9.5 175-191 GP14104 ppNPY GP14107 Neuropeptide Q2/NPQ2 GP14109 Substance P-Pure GP14110 Agouti-Related Protein GT15023 Agouti-Related Protein (Human) GT15040 ACE/CD143 GT15145 Neurotensin Receptor 3 (NTS3)/Sortilin GT15237 Substance P MO15094 Orexin B MO15114 PGP9.5 MO20002 PGP9.5 (Clone: 31A3) MO25010 PGP9.5 RA12103 NPY Y2 Receptor RA14112 Enkephalin, pre-pro (ppENK) RA14124 Neuropeptide Q/NPQ RA14131 Neuropeptide Q3/NPQ3 RA14134 NPY Y2 Receptor-C/N Terminus RA14136 CCK A Receptor RA15049 Neurotensin Receptor 2 (NTS2) RA17100 Neuropeptide FF1 Receptor RA19017 Neuropeptide FF2 Receptor RA19018 FMRFamide RA20002 Substance P RA20064 VIP RA20077 CCK-8 (Cholecystokinin Octapeptide) RA20078 beta-Lipotropin RA21003 Met-Enkephalin RA21006 Leu-Enkephalin RA21007 CGRP RA24112 NPY Y1 Receptor RA24506 NPY RA24603 Neurokinin-3 (NK 3) Receptor RA25002 Neurokinin-1 (NK 1) Receptor RA25003 Somatostatin Receptor-1-SSTR1 RA25004 Somatostatin Receptor-2-SSTR2 RA25005 proNeurokinin B (proNKB or P2) RA25008 Neurokinin-2 (NK 2) Receptor RA30006