Product Details
Catalog Number: RA14128
Applications: ICC, WB, IHC
Type: Rabbit IgG
Immunogen: APQPGLASPDSPHDPCK
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 4440
UniProt: O43347
Downloads: Datasheet (pdf)
Product Sizes
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50 ul$250.00Add to Cart

Musashi1, a neural RNA-binding protein, plays an important role in regulating cell differentiation in precursor cells. Musashi-1 (Msi-1) has been shown to increase the accumulation of tau isoforms in intracellular inclusions in dementia and Parkinson's. The presence of Msi-1 in a significant percentage of neurons containing cytoplasmic inclusions in 2 other neurodegenerative diseases Alzheimer's disease and Pick disease suggests that it may play a role in the pathogenesis of these neurodegenerative disorders.

Musashi1 has also been detected in human tumor tissues such as gliomas and melanomas, suggesting its involvement in cancer development. Msi-1 also appears to play be an vital role in the development of several types of carcinoma such as human hepatoma, and may be a useful molecular marker for tumor detection.

Images

Musashi (green) staining of neural rosettes(human). Nuclei are counterstained blue (DAPI). Image courtesy of Drs. Patricia Wilson and Steve Stice, University of Georgia.

Musashi (green) staining of neural rosettes(human). Nuclei are counterstained blue (DAPI). Image courtesy of Drs. Patricia Wilson and Steve Stice, University of Georgia.

Musashi-positive cells in the ventricular zone of E14.5 mouse medulla. Picture was taken at 200x magnification. The sections are 4% PFA fixed, paraffin-embedded and cut at 5 micron. Courtesy of Xi Huang, Chiang Lab, VUMC.

Musashi-positive cells in the ventricular zone of E14.5 mouse medulla. Picture was taken at 200x magnification. The sections are 4% PFA fixed, paraffin-embedded and cut at 5 micron. Courtesy of Xi Huang, Chiang Lab, VUMC.

Immunostaining of hNP1 Progenitors before and after differentiation. The culture was highly homogenous with neural rosettes. DOI: 10.1111/j.1432-0436.2007.00256.x.

Immunostaining of hNP1 Progenitors before and after differentiation. The culture was highly homogenous with neural rosettes. DOI: 10.1111/j.1432-0436.2007.00256.x.